Group Leader - Bioprocess Technologies
Marrone Bio Innovations
Davis, CA

About $41,000 - $57,000 a year

Marrone Bio Innovations is a publicly traded company (NASDAQ symbol “MBII”) in Davis, California, that discovers, develops, manufactures and markets effective and environmentally responsible bio-based products for pest management and plant health.

MBI is seeking an experienced scientist/engineer to lead the Bioprocess R&D team to support fermentation and downstream process development activities. He/she will be part of our R&D team responsible for understanding, developing and improving bioprocesses for new and existing products, transferring processes from R&D to Marrone Michigan Manufacturing (MMM) facility in Bangor, Michigan, and other Contract Manufacturing Facilities.

Overall management responsibility for day-to-day functions of the Fermentation and Downstream Process Development team including directing, mentoring, maintaining and improving all functions of the team members, Process Research Labs and the Pilot Plant.
Serve as a critical, core functional link between early stage biological development and late stage engineering technology transfer functions.
Provide Hands-on support during technical transfer of manufacturing processes (fermentation and downstream processing) from Davis to MMM and third party contract manufacturing facilities including visits to third party manufacturing sites when required.
Collaborate with R&D teams (Formulations, Pest Biology, Plant Biology and Chemistry) to identify novel bioactives and to develop potent and commercially viable/desirable formulations for the microbial end-products for Product Development and Manufacturing functions.
Advance the physiological process database of novel, industrially useful microbes by applying advanced analytical methodologies including OMICs tools to support the production of highly effective, novel bioactive products for agricultural pest management and plant health applications.
Apply innovative and advanced analytical bioprocessing technologies to develop scalable and cost-effective bioprocesses.
Manage and champion the preparation of batch records, laboratory notebooks, technical reports, summaries, protocols, and methods for characterization of microbial production strains and bioprocesses under GLP guidelines to support QC/QA and Regulatory functions.
Support scale-up of initial production runs of the bioprocesses for new products as well as debug the existing processes, as required by traveling to Bangor, MI and other CMO sites, as necessary.
Work with the Supply Chain department for recommending and qualifying raw materials for use in Manufacturing.

A Ph.D. degree in Microbiology, Biochemistry, (Bio)Chemical Engineering or related field with a minimum of 5+ years of industrial experience in microbial production of industrially useful products including physiology and biochemical engineering principle-based process optimization and scale-up with a minimum of 3-5 years in leading and mentoring a team of fermentation technicians, scientists and engineers.

Knowledge, Skills, and Abilities

Hands-on experience with research to pilot scale fermentation and downstream equipment developing practical, reproducible and scalable fermentation and downstream processes.
Collaborate with a multi-disciplinary team of scientists and engineers to develop advanced knowledge-base of microbes and their bioactivities in a controlled process environment.
Demonstrated entrepreneurial creativity, innovation, flexibility and accountability to troubleshoot biological and engineering challenges with scale up, yield enhancement and process cost reduction of new microorganisms.
Knowledge in Design of Experiments-based media development of microbial fermentation to increase biomass yield and the production of secondary metabolites.
Thorough understanding of microbial physiology of Gram-negative and Gram-positive bacteria, filamentous microbes, and fungi.
Knowledge of classical and recombinant strain improvement programs directed towards improving the properties of the microbial strains.
Experience in applying directed biosynthesis, fed-batch and continuous culture techniques for improved yields of fermentation processes.
Pertinent experience in Process Analytical technologies-based process development of microbial fermentations to increase biomass yield and the production of secondary metabolites.
Must have a thorough understanding of analytics and statistics as applied to all processes.
Experience (minimum 3-5 Years) in downstream processing of microbial products at a manufacturing scale.
Broad exposure or experience with lab, pilot and manufacturing equipment Experience in technical transfer of processes to manufacturing facilities.
Demonstrated success in participating with Process Engineering and Process Implementation teams to design and implement manufacturing process from inception to completion.
Excellent analytical and organizational skills, able to manage multiple priorities and delegate responsibilities while maintaining quality.
Independent, energetic and self-motivated individual able to work in a fast-paced team environment with tight schedule.
Must have strong written and verbal communications skills; Responsive; Able to work effectively as part of a team.
Proficiency in good record keeping, writing and revising technical reports and SOPs. Excellent technical software skills, including fermentation control and data analysis.
Experienced in GLP practices and mentoring staff to train and maintain staff for GLP practices.


The candidate must have experience (minimum 5 years) at supervising and motivating technical staff (technicians, scientists, and engineers).
Management and coaching of the team with attention to the development of required skill sets of the individuals involved
Must have excellent team building and project management skills.
Guide employees with scientific and technical knowledge to navigate through aggressive timelines in a multi-tasking environment.
Oversight and management of training requirements.
Technical Oversight of fermentation and downstream process scale up efforts to ensure expected performance.
Ensure adequate process monitoring including real time review of process parameters and process data/trend analysis.
Support of the laboratory safety program.
Ensure adequate resolution of operational variances, investigations, etc.
Support of audits including walkthroughs, responses, and completion of any suggestions for improvement in internal controls.
Promotion of a positive, respectful, responsive, innovative and team based culture.
The above is a list of essential duties and responsibilities for this position. This list is not all-inclusive. This job description may be modified as needed.

MBI requires a pre-employment drug screen. MBI is an equal-opportunity employer.