Inscripta is developing the world's first scalable platform for benchtop Digital Genome Engineering. The company’s advanced CRISPR-based platform, consisting of an instrument, reagents, and software, will offer a fully automated workflow that enables multiplexed, trackable editing of cells at an unprecedented scale. Inscripta’s goal is to empower scientists whose gene editing research is stifled by current technical and licensing limitations. By providing this unique platform and engaging in collaborative business practices, such as making its MAD7 CRISPR nuclease free for research purposes, the company enables scientists to realize a new era of biological discovery. Due to rapid growth Inscripta has an opening for a Staff Mechanical Engineer position in our Boulder, CO headquarters.
We are searching for an exceptional candidate with broad engineering background to play a key role developing new and improving existing DNA editing technology platforms to enable researchers around the world to efficiently engineer the genome. Candidates with a proven track record developing complex automated instrumentation and disposable fluidic cartridges will be considered. You will work closely with the microfluidics team to create innovative modules that enable high-throughput, robust, and automated single-cell genome editing from feasibility breadboards to production platforms.
- Contribute to the design of microfluidics cartridges and lead the development of the mechanical architecture to integrate them pneumatically, thermally, electrically, and optically to the macro environment. Solve complicated, interdisciplinary technology integration challenges.
- Design and build test fixtures and breadboards for submodules that interface with prototype microfluidics devices to support concept and feasibility phases.
- Contribute to the design of microfluidics cartridges and own the architecture of independent subsystems throughout development and subsequent integration into fully automated production instrument platforms.
- Perform DFX, tolerance analysis, and DFMEA.
- Critical parameter identification and management for reliable and robust lifetime performance.
- Develop methods to quantify and characterize performance of fluidic modules and associated components.
- Interface with external development partners and contract manufacturers
- Work collaboratively in a fast-paced environment with biologists, chemists, bioinformaticians, and engineers. Work under our high standards of experimental rigor.
- Present clear and concise written and oral communications to colleagues and supervisors, lead and/or participate in technical meetings.
- Bachelor or advanced degree in Mechanical Engineering with a minimum of 8 years of experience developing complex automated fluidic instrumentation and disposable cartridges
- Expertise in Solidworks.
- Experience with complex instrument platforms that manipulate cells and DNA using flow, electric, magnetic, and optical fields.
- Experience designing pneumatic and thermal/thermodynamic control systems.
- Experience with rapid prototyping of fluidic cartridges using machining, 3D printing, and proto injection molding, and bonding technologies including solvent bonding, PSAs, laser and ultrasonic welding, and lamination.
- Broad breadth of manufacturing technologies including precision micro-injection molding, low cost/high volume injection molding, and a network of manufacturing partners in the Americas, Europe, and Asia.
- Strong analytics and programming background. Strong quantitative, applied mathematics experience, and experience in at least one programming or scripting language such as C#, C++, Java, Matlab, R or Python.
- Materials characterization techniques, such as SEM, TEM, XPS, TOF-SIMS, AFM.
- Basic understanding of fluid dynamics at the micro scale.
- Basic understanding of the behavior and interaction of DNA, proteins and/or other biological systems.
- Demonstrated experience solving challenging, interdisciplinary research/development problems at the interface of fluidics, biology, chemistry and materials science leading fast-paced root cause identification efforts and implementing corrective action.
- A successful candidate will have an outstanding experimental background, a track record of creativity, a very strong theoretical acumen, first principle mindset and understanding of mechanical design, fluid dynamics, and materials.
Inscripta offers a competitive base salary, bonus plan, benefits package and stock options to all team members. Join us and work with a great team of people developing the world's first scalable platform for benchtop Digital Genome Engineering. Inscripta is headquartered in Boulder, CO with offices in Pleasanton and San Diego, CA. This position is located within our Boulder, CO headquarters.